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TET2

Tuesday 1 November 2016

Pathology

- Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.

  • Nature. 2018 Jul 18. doi : 10.1038/s41586-018-0350-5
  • Diabetes is a complex metabolic syndrome that is characterized by prolonged high blood glucose levels and frequently associated with life-threatening complications.
  • Epidemiological studies have suggested that diabetes is also linked to an increased risk of cancer.
  • High glucose levels may be a prevailing factor that contributes to the link between diabetes and cancer

Open references

- DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders. Sato H, Wheat JC, Steidl U, Ito K. Front Oncol. 2016 Aug 22;6:187. doi : 10.3389/fonc.2016.00187 PMID: 27597933 Free