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TMB and anti-PD1/PD-L1 response

Wednesday 2 November 2016

Tumor mutational load; TMB; tumor mutational burden

Links

- https://www.foundationmedicine.com/2016/10/newly-published-data-support-tmb-as-a-predictor-for-anti-pd-1pd-l1-response-in-melanoma/

- https://www.verywell.com/predicting-response-to-cancer-immunotherapies-4104640?utm_content=40642868&utm_medium=social&utm_source=twitter

Open references

- Johnson et al. Targeted next generation sequencing identifies markers of response to PD-1 blockade. Cancer Immunology Research. 2016. doi : 10.1158/2326-6066.CIR-16-0143

Paywall References

- Rizvi et al. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348(6230):124-128.