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Mallory bodies - Humpath.com - Human pathology

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Mallory bodies

Wednesday 14 December 2016

Mallory body

Definition: Subtype of intermediate filament inclusions seen in hepatocytes in a variety of liver diseases and in pneumocytes.

Mallory bodies contain keratin-8 (KRT8) and keratin-18 (KRT18).

Images

- amiodarone-associated hepatic anomalies

- Mallory bodies in alveolar pneumocytes (chemo-related lung injury)

Etiology

- alcoholic liver disease

- drug-associated hepatic anomalies

  • amiodarone-associated hepatic anomalies

- primary biliary cirrhosis (PBC)

Immunochemistry

- ubiquitin + (11338474, 2462130)

References

- Fickert P, Trauner M, Fuchsbichler A, Stumptner C, Zatloukal K, Denk H. Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins. J Hepatol 2003;38:387-394.

- Denk H, Stumptner C, Zatloukal K. Mallory bodies revisited. J Hepatol 2000;32:689-702.

- Jensen K, Gluud C. The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey). Hepatology. 1994 Oct;20(4 Pt 1):1061-77. PMID: 7927209

- Worman HJ. Cellular intermediate filament networks and their derangement in alcoholic hepatitis. Alcohol Clin Exp Res. 1990 Dec;14(6):789-804. PMID: 2088113

- French SW. Present understanding of the development of Mallory’s body. Arch Pathol Lab Med. 1983 Sep;107(9):445-50. PMID: 6192789