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HPV-related carcinoma with adenoid cystic-like features

Thursday 22 December 2016

HPV-related carcinoma with adenoid cystic-like features grows as basaloid nests, trabeculae, and cribriform structures. The surface exhibits squamous dysplasia.

Like adenoid cystic carcinoma, HPV-related carcinoma with adenoid cystic-like features is biphasic with myoepithelial cells that are positive for p63 and ducts that are positive for c-kit.

Both the invasive tumor and the dysplastic surface are positive for p16 by immunohistochemistry and HPV by in situ hybridization.

Images

- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746135/figure/Fig2/

Open references

- Newly Described Tumor Entities in Sinonasal Tract Pathology.
Bishop JA. Head Neck Pathol. 2016 Mar;10(1):23-31. doi : 10.1007/s12105-016-0688-7. Epub 2016 Feb 1. Review
PMID: 26830406 Free

- Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. Bishop JA, Ogawa T, Stelow EB, Moskaluk CA, Koch WM, Pai SI, Westra WH. Am J Surg Pathol. 2013 Jun;37(6):836-44. doi : 10.1097/PAS.0b013e31827b1cd6 PMID: 23598962 Free