Friday 6 January 2017
bHLHb26, "cell growth-inhibiting gene 8", GIG8; "inhibitor of differentiation 2", "inhibitor of DNA binding 2, dominant negative helix-loop-helix protein"
Definition: Inhibitor of DNA binding 2 (Id2), a helix-loop-helix protein of the inhibitor of differentiation (ID) family, is involved in hematopoiesis, mainly through interaction with the E-family of transcription factors.
Id2 is overexpressed in some types of B-cell lymphomas , including classical Hodgkin lymphoma.
The helix-loop-helix protein Id2 is expressed differentially and induced by MYC in T-cell lymphomas.
- Id2 commonly is overexpressed in highly proliferative T-cell lymphomas.
- Its expression may result from transcriptional activation of MYC in these tumors.
The helix-loop-helix protein Id2 is expressed differentially and induced by myc in T-cell lymphomas.
Cotta CV, Leventaki V, Atsaves V, Vidaki A, Schlette E, Jones D, Medeiros LJ, Rassidakis GZ.
Cancer. 2008 Feb 1;112(3):552-61.
PMID: 18085637 Free