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pathologic hyperplasia

Monday 9 January 2017

- Most forms of pathologic hyperplasia are caused by excessive hormonal stimulation or growth factors acting on target cells. Example: endometrial hyperplasia

- Pathologic hyperplasia, however, constitutes a fertile soil in which cancerous proliferation may eventually arise. Thus, patients with hyperplasia of the endometrium are at increased risk for developing endometrial cancer.

- Hyperplasia is also an important response of connective tissue cells in wound healing, in which proliferating fibro-blasts and blood vessels aid in repair.

- Under these circumstances, growth factors are responsible for the hyperplasia. Stimulation by growth factors is also involved in the hyperplasia that is associated with certain viral infections, such as papillomaviruses, which cause skin warts and a number of mucosal lesions composed of masses of hyperplastic epithelium.