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Friday 20 January 2017


Definition: BerEP4 : monoclonal antibody againt EPCAM It is an antibody to EpCAM (epithelial cell adhesion molecule).


- membranous BerEp4 expression in normal apocrine glands.

Diagnostic use

- Membranous staining
- basal cell carcinoma (BCC)

  • BerEp4 is a histologic stain mainly used to aid in the diagnosis of basal cell carcinoma (BCC).

- pulmonary adenocarcinoma

  • Sensitive and specific for lung adenocarcinoma (positive) vs. mesothelioma (negative) (, Am J Surg Pathol 2001;25:43)

- hepatocellular carcinoma vs cholangiocarcinoma

  • May help distinguish, as part of a panel, hepatocellular carcinoma (usually negative) from metastatic adenocarcinoma to liver or cholangiocarcinoma (usually positive, Mod Pathol 2002;15:1279)

Prognostic use

- Immunoexpression may predict poor survival in carcinomas of breast, gallbladder (Am J Clin Pathol 2008;129:424), ovary, pancreas

Open references

- Use of Ber-EP4 and Epithelial Specific Antigen to Differentiate Clinical Simulators of Basal Cell Carcinoma. Dasgeb B, Mohammadi TM, Mehregan DR. Biomark Cancer. 2013 Jun 25;5:7-11. doi : 10.4137/BIC.S11856 PMID: 24179394 Free

- The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. Sellheyer K, Nelson P, Kutzner H, Patel RM. J Cutan Pathol. 2013 Apr;40(4):363-70. doi : 10.1111/cup.12085 PMID: 23398472 Free

- Caveats in BerEP4 staining to differentiate basal and squamous cell carcinoma.
Yu L, Galan A, McNiff JM. J Cutan Pathol. 2009 Oct;36(10):1074-176. doi : 10.1111/j.1600-0560.2008.01223.x PMID: 19187107 Free