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IGF2BP3

Friday 17 February 2017

Pathology

- THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer. ( 28193878 )

- most IGF3BP3-THADA positive thyroid neoplasms are well circumscribed and have subtle nuclear alterations.

References

- THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer. Panebianco F, Kelly LM, Liu P, Zhong S, Dacic S, Wang X, Singhi AD, Dhir R, Chiosea SI, Kuan SF, Bhargava R, Dabbs D, Trivedi S, Gandhi M, Diaz R, Wald AI, Carty SE, Ferris RL, Lee AV, Nikiforova MN, Nikiforov YE. Proc Natl Acad Sci U S A. 2017 Feb 13. pii: 201614265. doi : 10.1073/pnas.1614265114 PMID: 28193878