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nuclear grooves

Wednesday 22 February 2017

nuclear groove; nuclear grooving

See also : coffee bean nuclei

Examples

- papillary thyroid carcinoma (PTC). Grooves & classic "orphan Annie eye" (empty round nuclei)

- Deeply clefted nuclei suspect follicular lymphoma t(14;18)(q32;q21)

Tumor types

- papillary thyroid carcinoma

  • Nuclear grooving is a useful morphologic feature in the diagnosis of papillary carcinoma of the thyroid (PTC) in tissue sections and imprint smears.
  • Nuclear grooving, when seen in abundance, can be considered a reliable criterion for the diagnosis of papillary carcinoma in fine needle aspiration cytology of the thyroid.
  • The presence of occasional grooves, however, should be regarded as a nonspecific finding.

- Langerahns histiocytosis

- granulosa cell tumor

  • Granulosa cell tumor has sheets of small cells with longitudinal nuclear grooves (“coffee bean nuclei”), and Call-Exner bodies (eosinophilic fluid filled spaces surrounded by granulosa cells). Most tumors cause hyperestrogenism.

See also

- PMID: 2916367

Examples

- papillary thyroid carcinoma
- ovarian benign Brenner tumor

Images

- ovarian benign Brenner tumor

See also

- nuclear anomalies