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H3K27me3

Monday 6 March 2017

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Definition: H3K27me3 is the trimethylated lysine residue at position 27 in the protein histone H3. H3K27me3 is known as a repressive mark because of its association with repression of gene expression.

EZH2 protein of polycomb repressive complex 2 (PRC2) transfers the methyl group to H3K27 and UTX in human removed the trimethylation in human.

Images

- H3K27me3 lost in majority of MPNST, retained in synovial sarcoma

- H3K27me3 immunostaining highlights multiple Barr bodies in polyploid cells of Schwannoma with prominent "ancient" change in a female patient.

Pathology

- melanoma

  • Reduced H3K27me3 Expression Is Common in Nodular Melanomas of Childhood Associated With Congenital Melanocytic Nevi But Not in Proliferative Nodules.
    (27849631)

- MPNST

  • Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST. (26645727)
  • Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival. (26990975)

Open references

- Reduced H3K27me3 Expression Is Common in Nodular Melanomas of Childhood Associated With Congenital Melanocytic Nevi But Not in Proliferative Nodules. Busam KJ, Shah KN, Gerami P, Sitzman T, Jungbluth AA, Kinsler V. Am J Surg Pathol. 2017 Mar;41(3):396-404. doi : 10.1097/PAS.0000000000000769 PMID: 27849631 Free

- Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival. Cleven AH, Sannaa GA, Briaire-de Bruijn I, Ingram DR, van de Rijn M, Rubin BP, de Vries MW, Watson KL, Torres KE, Wang WL, van Duinen SG, Hogendoorn PC, Lazar AJ, BovĂ©e JV. Mod Pathol. 2016 Jun;29(6):582-90. doi : 10.1038/modpathol.2016.45 PMID: 26990975 Free

- Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics. Schaefer IM, Fletcher CD, Hornick JL. Mod Pathol. 2016 Jan;29(1):4-13. doi : 10.1038/modpathol.2015.134 PMID: 26585554 Free