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H3K27me3

Monday 6 March 2017

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Definition: H3K27me3 is the trimethylated lysine residue at position 27 in the protein histone H3. H3K27me3 is known as a repressive mark because of its association with repression of gene expression.

EZH2 protein of polycomb repressive complex 2 (PRC2) transfers the methyl group to H3K27 and UTX in human removed the trimethylation in human.

Images

- H3K27me3 lost in majority of MPNST, retained in synovial sarcoma

Pathology

- melanoma

  • Reduced H3K27me3 Expression Is Common in Nodular Melanomas of Childhood Associated With Congenital Melanocytic Nevi But Not in Proliferative Nodules.
    (27849631)

- MPNST

  • Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST. (26645727)
  • Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival. (26990975)

Open references

- Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival. Cleven AH, Sannaa GA, Briaire-de Bruijn I, Ingram DR, van de Rijn M, Rubin BP, de Vries MW, Watson KL, Torres KE, Wang WL, van Duinen SG, Hogendoorn PC, Lazar AJ, BovĂ©e JV. Mod Pathol. 2016 Jun;29(6):582-90. doi : 10.1038/modpathol.2016.45 PMID: 26990975 Free

- Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics. Schaefer IM, Fletcher CD, Hornick JL. Mod Pathol. 2016 Jan;29(1):4-13. doi : 10.1038/modpathol.2015.134 PMID: 26585554 Free