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TSC2-deficient teratoma

Wednesday 8 March 2017

Tsc2-deficient teratomas

Model animal

The model animal of renal cell carcinoma (RCC), the Eker rat, has a germline mutation in the tuberous sclerosis 2 (Tsc2) gene. Heterozygous mutants develop RCCs by second hit in the wild-type Tsc2 allele, whereas homozygous mutants are embryonic lethal.

Open references

- Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway.
Kawano H, Ito Y, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Kobayashi T, Hino O.
Oncol Rep. 2015 Nov;34(5):2251-8. doi : 10.3892/or.2015.4254
PMID: 26352760 Free