cryptococcal inflammatory pseudotumor
Wednesday 15 March 2017
Cryptococcus-associated inflammatory pseudotumor
"Inflammatory pseudotumors" (IPTs) embrace a heterogeneous spectrum of reactive, infective, and neoplastic entities, that are characterized by a clinical mass composed of a histologic proliferation of spindle cells in a background of inflammatory cells and collagen fibers.
Although a spectrum of microorganisms have been identified in infective IPTs, mycobacterial infective IPTs are reported most commonly.
The specimens demonstrate a storiform arrangement of plump spindle cells, in addition to spindle and polygonal cells that are arranged in a haphazard manner.
Background lymphocytes, plasma cells, and fibrosis are noted, in addition to scattered giant cells and focal necrosis.
Immunophenotyping of the spindle cells confirmed a mixed histiocytic and myofibroblastic lineage, with a predominance of the former.
Cryptococcal inflammatory pseudotumors.
Sing Y, Ramdial PK.
Am J Surg Pathol. 2007 Oct;31(10):1521-7.