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Friday 21 April 2017

The proteostasis network (PN) regulates protein synthesis, folding, transport, and degradation to maintain proteome integrity and limit the accumulation of protein aggregates, a hallmark of aging and degenerative diseases.

Proteome integrity is maintained by the proteostasis network (PN), which consists of interconnected systems that regulate protein synthesis, folding, transport, and degradation in every cell.

The functionality of this network declines during aging, thus compounding the risk for diseases related to proteostasis dysfunction, such as neurodegenerative diseases, cardiomyopathies, and metabolic disorders.

Studies in yeast and tissue culture have provided fundamental insights into the molecular mechanisms of PN function and regulation within single cells.

Multicellular organisms, however, consist of different cell types that are structurally and functionally diverse, reflecting distinct proteomes.

Differentiation, specialization, and spatial organization of cells in complex organisms also influence the ability of individual cells to sense and respond to stressful stimuli.

Therefore, transcellular mechanisms are in place to orchestrate PN functionality across organs and tissues.

It involves the differential scales of proteostasis regulation from the cellular to the organismal level and discuss implications for human health.

See also

- multicellularity

Open References

- Shaping proteostasis at the cellular, tissue, and organismal level. 2017. doi : 10.1083/jcb.201612111 Free paper