Humpath.com - Human pathology

Home > A. Molecular pathology > P2X7R

P2X7R

Wednesday 26 April 2017

WKP

P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene.

The product of this gene belongs to the family of purinoceptors for ATP. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay criteria.

The receptor is found in the central and peripheral nervous systems, in microglia, in macrophages, in uterine endometrium, and in the retina.

The P2X7 receptor also serves as a pattern recognition receptor for extracellular ATP-mediated apoptotic cell death, regulation of receptor trafficking, mast cell degranulation, and inflammation.

Paywall references

- High expression of P2X7R is an independent postoperative indicator of poor prognosis in Colorectal cancer. 2017. doi : 10.1016/j.humpath.2017.03.019