Humpath.com - Human pathology

Home > E. Pathology by systems > Genital system > Female genital system > Uterus > Uterine cervix > cervical superficially invasive squamous cell carcinoma

cervical superficially invasive squamous cell carcinoma

Thursday 11 May 2017

Superficially invasive squamous cell carcinoma of the cervix.

Definition: Superficially invasive squamous cell carcinoma of the cervix is histologically defined as a superficially invasive (1-5 mm) squamous cell carcinoma.

According to FIGO standards, superficially invasive carcinoma of the cervix is @<@= 5 mm depth or 7 mm width.

Radical or modified radical hysterectomy with pelvic node dissection is usually performed for women with more than 1 mm invasion, whereas more conservative surgery was used when invasion was 1 mm or less.

Depth of stromal invasion was the most important variable in predicting pelvic lymph node metastases.

The overall incidence of pelvic node metastases was 5%, and the incidence of metastases in those patients with 3 mm or less and 3.1-5.0 mm of invasion was 2 and 13%, respectively.

Although the risk of node metastases was significantly higher with deeper invasion, one patient with 2 mm of invasion had pelvic node involvement.

Microscopic lymph-vascular invasion and degree of lateral spread of tumor were also associated with lymph node metastases, whereas tumor grade was not. There were no invasive recurrences in the series.

Histomorphologic variables other than depth of stromal invasion should be considered when evaluating patients with superficially invasive squamous cell carcinoma of the cervix. (3405556)

References

- Superficially invasive squamous cell carcinoma of the cervix.
Maiman MA, Fruchter RG, DiMaio TM, Boyce JG.
Obstet Gynecol. 1988 Sep;72(3 Pt 1):399-403.
PMID: 3405556