prostatic basal cell hyperplasia
Thursday 11 May 2017
Basal cell hyperplasia is surrounded by a well organized basal cell layer and stroma without desmoplasia. No atypical mitotic figures are present, and benign prostate glands are embedded within the the benign cellular proliferation. By IHC, basal cells stain for HMWCK (CK903/ 34BE12) and p63.
Basal cell hyperplasia is usually seen in the transition zone.
Occasionally, it may be encountered in needle biopsies (which sample peripheral zone).
The nuclei are ovoid or round with finely reticular chromatin and rare punctate nucleoli.
The cytoplasm is pale eosinophilic or clear.
In rare instances, basal cell hyperplasia shows prominent nucleoli. This is referred to as atypical basal cell hyperplasia. In most cases, this is in response to inflammation nearby.