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atypical small acinar proliferation

Monday 15 May 2017


Atypical small acinar proliferation (ASAP) occurs in approximately 5% of prostate biopsies.

Approximately 30-40% of patients with ASAP may develop prostate cancer (PCa) within a 5-year period.

Current guidelines recommend a repeat biopsy within 3-6 months after the initial diagnosis.

Open references

Atypical Small Acinar Proliferation: Repeat Biopsy and Detection of High Grade Prostate Cancer.
Leone A, Rotker K, Butler C, Mega A, Li J, Amin A, Schiff SF, Pareek G, Golijanin D, Renzulli JF 2nd.
Prostate Cancer. 2015;2015:810159. doi : 10.1155/2015/810159
PMID: 26451257 Free

Paywall references

Prostate cancer detection following diagnosis of atypical small acinar proliferation.
Ericson KJ, Wenger HC, Rosen AM, Kiriluk KJ, Gerber GS, Paner GP, Eggener SE.
Can J Urol. 2017 Apr;24(2):8714-8720.
PMID: 28436357

Atypical small acinar proliferation (ASAP): Is a repeat biopsy necessary ASAP? A multi-institutional review.
Leone A, Gershman B, Rotker K, Butler C, Fantasia J, Miller A, Afiadata A, Amin A, Zhou A, Jiang Z, Sebo T, Mega A, Schiff S, Pareek G, Golijanin D, Yates J, Karnes RJ, Renzulli J.
Prostate Cancer Prostatic Dis. 2016 Mar;19(1):68-71. doi : 10.1038/pcan.2015.52
PMID: 26857145