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salivary cribriform adenocarcinoma

Monday 26 June 2017


Definition: Cribriform adenocarcinoma (CASG) is a distinct tumor entity that differs from polymorphous low-grade adenocarcinoma by location (ie, most often arising on the tongue), by prominent nuclear clearing, differing alterations of the PRKD gene family, and clinical behavior with frequent metastases at the time of presentation of the primary tumor.

Early nodal metastatic disease is seen in most cases of CASG; yet, they are still associated with indolent clinical behavior, making it a unique neoplasm among all low-grade salivary gland tumors.

Paywall references

Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A.
Am J Surg Pathol. 2017 Jun 13. doi : 10.1097/PAS.0000000000000883
PMID: 28614209