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urothelial cells with jet black chromatin

Saturday 6 January 2018

Urothelial cells with jet black chromatin are mainly tubular cells.

Some high-grade urothelial carcinomas (UCs) in urine cytology can have jet black, smooth, or glassy chromatin.

Compared with tubular cells that also often have jet black chromatin, the nuclei of high-grade urothelial carcinoma cells are larger & irregular, have nuclear “points", & have a sickle or half-moon shape.

Malignant urothelial cells in urine cytology with jet black chromatin are common and can be diagnosed as “positive for malignancy” based on their irregular nuclear outline, increased cellularity (≥50 abnormal cells), and frequent necrosis.

Paywall references

- High-grade urothelial carcinoma in urine cytology with jet black and smooth or glassy chromatin. 2017. doi : 10.1002/cncy.21947