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salivary basal cell adenoma with cribriform pattern

Friday 9 February 2018

Definition: Subtype of salivary basal cell adenoma.

Differential diagnosis

- adenoid cystic carcinoma (AdCC)

  • Cribriform type of salivary basal cell adenoma (cBCA) is relatively rare and problematic in distinction from adenoid cystic carcinoma (AdCC).
  • Good circumscription, lack of infiltrative properties, and absence of MMP9, laminin, CD117, and myoepithelial marker (SMA, S100 and calponin) in the cells around the cribriform spaces, are the most reliable points for differential diagnosis of cBCA from AdCC. (24206768)

Paywall references

- Basal cell adenoma of salivary glands with a focal cribriform pattern: clinicopathologic and immunohistochemical study of 19 cases of a potential pitfall for diagnosis. Li BB, Zhou CX, Jia SN. Ann Diagn Pathol. 2014 Feb;18(1):5-9. doi : 10.1016/j.anndiagpath.2013.09.002 PMID: 24206768