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FRS2

Friday 13 July 2018

WKP

Definition: Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.

Pathology

FRS2 is overexpressed and amplified in several cancer types, including prostate cancer.

Low-grade osteosarcoma (LGOS) encompasses low-grade central osteosarcoma (LGCOS) and parosteal osteosarcoma (POS).

LGOSs are characterized by a supernumerary ring and giant rod chromosomes containing the 12q13-15 amplicon.

The fibroblast growth factor receptor substrate 2 (FRS2) gene is located close to MDM2 and CDK4.

Recent studies identified consistent amplification of FRS2 gene in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma.

Paywall References

- Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis. He X, Pang Z, Zhang X, Lan T, Chen H, Chen M, Yang H, Huang J, Chen Y, Zhang Z, Jing W, Peng R, Zhang H. Am J Surg Pathol. 2018 Jul 11. doi : 10.1097/PAS.0000000000001125 PMID: 30001240