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mixed adenoma well-differentiated neuroendocrine tumor

Friday 13 July 2018

Mixed Adenoma Well-differentiated Neuroendocrine Tumor (MANET) of the Digestive System

Definition : Mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN) consisting of adenoma and well-differentiated neuroendocrine tumor (NET) has been recently defined as "MANET."

Like mixed adenoneuroendocrine carcinomas, a high-grade malignant form of MiNENs with a poorly differentiated neuroendocrine carcinoma component, a common origin for both tumor constituents may be hypothesized.

MANET is an indolent disease that needs to be distinguished from aggressive high-grade MiNENs.

Paywall references

- Mixed Adenoma Well-differentiated Neuroendocrine Tumor (MANET) of the Digestive System: An Indolent Subtype of Mixed Neuroendocrine-NonNeuroendocrine Neoplasm (MiNEN). La Rosa S, Uccella S, Molinari F, Savio A, Mete O, Vanoli A, Maragliano R, Frattini M, Mazzucchelli L, Sessa F, Bongiovanni M. Am J Surg Pathol. 2018 Jul 11. doi : 10.1097/PAS.0000000000001123 PMID: 30001239