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prostate transition zone

Tuesday 25 July 2017

The prostate gland contains three major glandular regions :
- the peripheral zone ,
- the central zone,
- the transition zone .

The central zone is relatively resistant to carcinoma and other disease; the transition zone is the main site of origin of prostate hyperplasia. There are also several important non-glandular regions concentrated in the anteromedial portion of the gland.

Each glandular zone has specific architectural and stromal features. In all zones, both ducts and acini are lined by secretory epithelium. In each zone, there is a layer of basal cells beneath the secretory lining, as well as interspersed endocrine-paracrine cells.

Frequent deviations from normal histology include post-inflammatory atrophy , basal cell hyperplasia , benign nodular hyperplasia , atypical adenomatous hyperplasia , and duct-acinar dysplasia.

These lesions may at times be confused with carcinoma, especially in biopsy material.