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NCOA4

Tuesday 21 August 2018

WKP

NCOA4 / Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.

It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.

Pathology

Molecular profiling of salivary gland intraductal carcinoma revealed a subset of tumors harboring NCOA4-RET and novel TRIM27-RET fusions. (30045065)