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MEIS1-NCOA2-associated renal sarcoma

Thursday 6 September 2018

Some renal sarcomas are characterized by a MEIS1-NCOA2 gene fusion.

These neoplasms did not have a distinctive immunohistochemical profile, though both labeled for TLE1.

The morphologic features are distinct from other sarcomas associated with NCOA2 gene fusions, including mesenchymal chondrosarcoma, congenital/infantile spindle cell rhabdomyosarcoma, and soft tissue angiofibroma.

The aggressive histologic features of these neoplasms indicate malignant potential, thus warranting classification as a novel subtype of sarcoma.

See also

- MEIS1
- NCOA2

Paywall references

- Novel MEIS1-NCOA2 Gene Fusions Define a Distinct Primitive Spindle Cell Sarcoma of the Kidney. Argani P, Reuter VE, Kapur P, Brown JE, Sung YS, Zhang L, Williamson R, Francis G, Sommerville S, Swanson D, Dickson BC, Antonescu CR. Am J Surg Pathol. 2018 Aug 31. doi : 10.1097/PAS.0000000000001140 PMID: 30179902