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EBV-associated pulmonary carcinoma

Friday 26 October 2018

Lymphoepithelioma-like carcinoma (LELC) of the lung

Lymphoepithelioma-like carcinoma (LELC) of the lung is a rare Epstein-Barr virus (EBV)-associated carcinoma. It is histologically characterized by a syncytial growth pattern with marked lymphocytic infiltration that is indistinguishable from the histology observed in undifferentiated nasopharyngeal carcinomas. However, it has been noted that LELC can display nonclassic morphology and lack significant lymphocytic infiltration.

Patients with tumors exhibiting granulomatous inflammation have favorable outcomes; however, spread through alveolar spaces did not significantly correlate with prognosis. (30334830)

As many of these "LELCs" do not resemble undifferentiated nasopharyngeal carcinoma or lymphoepithelioma, it has been proposed using an alternative term, EBV-associated pulmonary carcinoma, to encompass the entire morphologic spectrum of this distinct disease entity. (30334830)

Paywall references

- Epstein-Barr Virus-associated Pulmonary Carcinoma: Proposing an Alternative Term and Expanding the Histologic Spectrum of Lymphoepithelioma-like Carcinoma of the Lung. Yeh YC, Kao HL, Lee KL, Wu MH, Ho HL, Chou TY. Am J Surg Pathol. 2018 Oct 16. doi : 10.1097/PAS.0000000000001173 PMID: 30334830