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TRAFs

Friday 23 November 2018

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Definition : TNF receptor associated factors also known as TRAFs are a family of proteins primarily involved in the regulation of inflammation, antiviral responses and apoptosis.

Currently, seven TRAF proteins have been characterized in mammals: TRAF1 , TRAF2 , TRAF3 , TRAF4 , TRAF5 , TRAF6 and TRAF7.

Except for TRAF7 , these proteins share a relatively conserved secondary structure, including a namesake C-terminal TRAF domain that mediates interactions with other signaling components such as the transmembrane TNF receptors and CD40.