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Home > E. Pathology by systems > Reproductive system > Male genital system > Prostate > central zone

central zone

Saturday 9 February 2019


Definition : CZ surrounds the ejaculatory ducts. The central zone accounts for roughly 2.5% of prostate cancers; these cancers tend to be more aggressive and more likely to invade the seminal vesicles.

Glands of central zone at the base of the prostate can mimic high-grade PIN architecturally.

There is nuclear crowding and pseudostratification with tufted, papillary and even cribriform areas within the glands.

Central zone glands may sometimes be seen at the end of a prostate biopsy core admixed with smooth muscle of bladder neck.

They lack nuclear enlargement and hyperchromasia and don’t have prominent nucleoli.