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ADRB1

Monday 2 September 2019

Pathology

- A mutation in ADRB1 leads to natural short sleep trait in humans
- Mice engineered with same mutation have similar short sleep behavior as humans
- Activity of dorsal pons ADRB1+ neurons associates with REM sleep and wakefulness
- Mutation increases the population activity of dorsal pons ADRB1+ neurons

References

- A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors. 2019
doi.org:10.1016/j.neuron.2019.07.026.