Humpath.com - Human pathology

Home > E. Pathology by systems > Reproductive system > Female genital system > Vulva > usual differentiated vulvar intraepithelial neoplasia

usual differentiated vulvar intraepithelial neoplasia

Wednesday 11 September 2019

usual differentiated VIN

- usual differentiated vulvar intraepithelial neoplasia p16+

  • "usual type" or "classic type", related to human papillomavirus (HPV) infection and affecting relatively young women
  • The usual type includes warty type, basaloid type and mixed (warty and basaloid) type.
  • The usual type is HPV associated - it is positive for p16, negative or has low indices for p53, and MIB-1 is strongly positive above the basal layer.
  • VIN, usual type (including the sub-categories warty type and basaloid type) are associated with HPV.
  • They are HPV and p16 positive, negative for p53, and MIB-1 is strongly positive above the basal layer.
  • Usual VIN (warty and basaloid types): Premenopausal, HPV positive, p16 positive, low / negative p53, MIB-1 suprabasal.