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NTRK3-rearranged fusiform cell tumors

Friday 8 November 2019

soft tissue spindle cell tumors with NTRK3 gene rearrangements

NTRK3-rearranged tumors other than infantile fibrosarcomas (IFSs) harboring the canonical ETV6-NTRK3 fusions are uncommon, and include mainly inflammatory myofibroblastic tumors and gastrointestinal stromal tumors.

Examples

- NTRK3-rearranged fibrosarcoma

References

- The histologic spectrum of soft tissue spindle cell tumors with NTRK3 gene rearrangements. Suurmeijer AJ, Dickson BC, Swanson D, Zhang L, Sung YS, Huang HY, Fletcher CD, Antonescu CR. Genes Chromosomes Cancer. 2019 Nov;58(11):739-746. doi : 10.1002/gcc.22767 PMID: 31112350

- Croce S, Hostein I, Longacre TA, Mills AM, PĂ©rot G, Devouassoux-Shisheboran M, Velasco V, Floquet A, Guyon F, Chakiba C, Querleu D, Khalifa E, Mayeur L, Rebier F, Leguellec S, Soubeyran I, McCluggage WG. Mod Pathol. 2019 Jul;32(7):1008-1022. doi : 10.1038/s41379-018-0184-6 PMID: 30877273