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oral squamous cell papilloma
Friday 13 December 2019
oral squamous papilloma; oral malpighian cell papilloma
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Definition : Oral squamous cell papilloma is a common intraoral benign epithelial neoplasm. 50% are associated with human papillomavirus (HPV 6 and 11). Others are probably reactive epithelial hyperplasia
Synopsis :
white-pink cauliflower-like surface projections
75% are less than 1 cm
fibrovascular cores surrounded by benign squamous epithelium
hyperkeratosis in 82%, parakeratosis in 72%
variable hyperplasia of basilar cell layer , parabasilar cell layer, prickle cell cell layer or granular cell layer , individual cell keratinization and abnormal mitotic figures
Often no koilocytotic changes ;
no downward pushing growth into lamina propria
possible epithelial dysplasia: significant cytologic atypia and maturation anomalies
Sites: posterior hard palate, soft palate and uvula (34%), dorsum and lateral tongue borders (24%), gingiva (12%), lower lip (12%) and buccal mucosa (6%)
Differential diagnosis :
multiple lesions
- focal dermal hypoplasia ( Goltz-Gorlin syndrome )
- focal epithelial hyperplasia ( Heck disease )
- inflammatory papillary hyperplasia
- juvenile papillomatosis
- papillary appearing lymphoid hyperplasia of tonsils
solitary lesions
- condyloma acuminatum
- verrucae vulgaris
- verrucous carcinoma
See also
oral anomalies
squamous cell papilloma
papillomatoses / papillomatosis