oral squamous cell papilloma

Definition : Oral squamous cell papilloma is a common intraoral benign epithelial neoplasm. 50% are associated with human papillomavirus (HPV 6 and 11). Others are probably reactive epithelial hyperplasia

Synopsis :
 white-pink cauliflower-like surface projections
 75% are less than 1 cm
 fibrovascular cores surrounded by benign squamous epithelium
 hyperkeratosis in 82%, parakeratosis in 72%
 variable hyperplasia of basilar cell layer , parabasilar cell layer, prickle cell cell layer or granular cell layer , individual cell keratinization and abnormal mitotic figures
 Often no koilocytotic changes ;
 no downward pushing growth into lamina propria
 possible epithelial dysplasia: significant cytologic atypia and maturation anomalies

Sites: posterior hard palate, soft palate and uvula (34%), dorsum and lateral tongue borders (24%), gingiva (12%), lower lip (12%) and buccal mucosa (6%)

Differential diagnosis :

 multiple lesions

• focal dermal hypoplasia ( Goltz-Gorlin syndrome )
• focal epithelial hyperplasia ( Heck disease )
• inflammatory papillary hyperplasia
• juvenile papillomatosis
• papillary appearing lymphoid hyperplasia of tonsils

 solitary lesions

• condyloma acuminatum
• verrucae vulgaris
• verrucous carcinoma

See also

 oral anomalies
 squamous cell papilloma
 papillomatoses / papillomatosis