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giant cell angioblastoma

Wednesday 11 February 2004

Locally aggressive soft-tissue tumor.


- solid, nodular, and plexiform proliferation of oval-to-spindle cells
- frequent striking, concentric aggregation around small vascular channels
- nodular cell clusters resembling inflammatory granulomas
- giant, multinucleated cells.


- cellular aggregates were interpreted as distorted attempts at formation of vessels.


- stromal cells positive for factor XIIIa
- stromal cells positive for histocompatability antigen (HLA)-DR


- Vargas SO, Perez-Atayde AR, Gonzalez-Crussi F, Kozakewich HP. Giant cell angioblastoma: three additional occurrences of a distinct pathologic entity. Am J Surg Pathol. 2001 Feb;25(2):185-96. PMID: 11176067

- Gonzalez-Crussi F, Chou P, Crawford SE. Congenital, infiltrating giant-cell angioblastoma. A new entity? Am J Surg Pathol. 1991 Feb;15(2):175-83. PMID: 1989466