- Human pathology

Home > A. Molecular pathology > PRKD1


Wednesday 28 October 2020


Definition : Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.

Members of the protein kinase D ( PKDs ) family function in many extracellular receptor-mediated signal transduction pathways.

ThePRKD1 / PRKCM gene encodes a cytosolic serine-threonine kinase that binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface.


- polymorphous adenocarcinoma of the salivary gland harbor genetic alterations affecting PRKD genes. PMID: 31492931

- The PRKD1 E710D hotspot mutation is highly specific in separating polymorphous adenocarcinoma of the palate from adenoid cystic carcinoma and pleomorphic adenoma on FNA. PMID: 29266837