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ETSs

Tuesday 2 March 2004

The ETSs proteins are transcription factors which activate transcription by interaction with purine-rich sequences present in the promoter/enhancer region of the TCRA gene (MIM.186880).

Members

ETSs ETS1 ETS2
FLI1 ERG FEV
ELKs ELK1 ELK2
ETVs ETV1 ETV2 ETV3 ETV4 ETV5 ETV6

The several classes of ETS family members could be due to an ancestral gene duplication, followed by genetic recombination(s) or divergence. Since all of the classes are present in both invertebrates and vertebrates, such an ancestral duplication must predate the emergence of chordates more than 500 million years ago.

Pathology

- overexpression of the ETSs genes in the majority of prostate cancers

  • gene fusions of the 5’-untranslated region of TMPRSS2 (21q22.3) with the ETS transcription factor family members, either ERG (21q22.2), ETV1 (7p21.2), or ETV4 (17q21) (16951139)

References

- Perner S, Demichelis F, Beroukhim R, Schmidt FH, Mosquera JM, Setlur S, Tchinda J, Tomlins SA, Hofer MD, Pienta KG, Kuefer R, Vessella R, Sun XW, Meyerson M, Lee C, Sellers WR, Chinnaiyan AM, Rubin MA. TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer. Cancer Res. 2006 Sep 1;66(17):8337-41. PMID: 16951139

- Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, Lee C, Montie JE, Shah RB, Pienta KJ, Rubin MA, Chinnaiyan AM. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 2005 Oct 28;310(5748):644-8. PMID: 16254181