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caveolae

Monday 9 June 2003

Caveolae are small plasmalemmal vesicles of distinct, flask-shaped morphology. Caveolae are formed through the oligomerization of its structural proteins, caveolin-1 and caveolin-2, to form distinctive coat appearing as bipolar-oriented, thin striations surrounding the bulb of the caveloa.

Membrane microdomains such as caveolae are sites of signal transduction. Many cell types including fibroblasts and endothelial cells contain small flask shaped invaginations of the plasma membrane. These structures are enriched in various signaling molecules including cell surface receptors that are attached by a lipid anchor.

Caveolae are 50-100 nm invaginations of the plasma membrane. The caveolins are a family of proteins intimately involved in caveolar function.

Caveolae and caveolins are involved in a variety of cellular processes including endocytosis, lipid homeostasis, signal transduction, and tumorigenesis.

Roles

- endocytosis
- lipid homeostasis
- signal transduction
- tumorigenesis

Features

- caveolae trafficking

Role

- transcytosis
- endocytosis

Anomalies - Structural alterations of caveolae

References

- Parton RG, Simons K. The multiple faces of caveolae. Nat Rev Mol Cell Biol. 2007 Mar;8(3):185-94. PMID: 17318224

- Carver LA, Schnitzer JE. Caveolae: mining little caves for new cancer targets. Nat Rev Cancer. 2003 Aug;3(8):571-81. PMID: 12894245

- van Deurs B, Roepstorff K, Hommelgaard AM, Sandvig K. Caveolae: anchored, multifunctional platforms in the lipid ocean. Trends Cell Biol. 2003 Feb;13(2):92-100. PMID: 12559760

- Galbiati F, Razani B, Lisanti MP. Caveolae and caveolin-3 in muscular dystrophy. Trends Mol Med. 2001 Oct;7(10):435-41. PMID: 11597517

- Couet J, Belanger MM, Roussel E, Drolet MC. Cell biology of caveolae and caveolin. Adv Drug Deliv Rev. 2001 Jul 28;49(3):223-35. PMID: 11551396

- Gumbleton M, Abulrob AG, Campbell L. Caveolae: an alternative membrane transport compartment.
Pharm Res. 2000 Sep;17(9):1035-48. PMID: 11087034

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