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salivary duct carcinoma

Monday 8 March 2004

SDC

Definition: Salivary duct carcinoma (SDC) is an aggressive adenocarcinoma of the salivary glands associated with poor clinical outcome.

Images

- salivary duct carcinoma

- SDC diagnostic algorythm

Immunochemistry

- 98% of salivary duct carcinomas are apocrine/androgen receptor positive ( AR+ )

Molecular biology

- SDCs are known to carry TP53 mutations in about 50%, however, only little is known about alternative pathogenic mechanisms within the p53 regulatory network.

- 12q13-15 amplification
- Subgroups of SDCs display genomic amplifications of MDM2 and/or CDK4 , partly in association with TP53 mutations and rearrangement/amplification of HMGA2.

- PLAG1 rearrangements (27379604, 23738717)

- HMGA2 rearrangements (27379604, 23738717)

See also

- salivary gland tumors

Open references

- Clinicopathological features and treatment outcomes of the rare, salivary duct carcinoma of parotid gland. Al-Qahtani KH, Tunio MA, Bayoumi Y, Gurusamy VM, Bahamdain FA, Fatani H. J Otolaryngol Head Neck Surg. 2016 May 16;45(1):32. doi : 10.1186/s40463-016-0146-2 PMID: 27184361 (Free)

- Salivary duct carcinoma: A clinopathological report of 11 cases. Huang X, Hao J, Chen S, Deng R. Oncol Lett. 2015 Jul;10(1):337-341. PMID: 26171026 (Free)

Paywall references

- Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations.
Chiosea SI, Thompson LD, Weinreb I, Bauman JE, Mahaffey AM, Miller C, Ferris RL, Gooding WE.
Cancer. 2016 Oct 15;122(20):3136-3144. doi : 10.1002/cncr.30179
PMID: 27379604

- An analysis of PLAG1 and HMGA2 rearrangements in salivary duct carcinoma and examination of the role of precursor lesions.
Bahrami A, Perez-Ordonez B, Dalton JD, Weinreb I.
Histopathology. 2013 Aug;63(2):250-62. doi : 10.1111/his.12152
PMID: 23738717

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