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juvenile polyp

Thursday 18 March 2004

Definition: Juvenile polyps are hamartomatous polyps found primarily in infants and children. Hamartomatous polyp that may occur sporadically or as part of polyposis syndrome.


- Enterobius vermicularis in a juvenile polyp

Clinical synopsis

Patients usually present at early age with anemia, diarrhea, or bleeding
Juvenile polyposis syndrome patients typically have between 50-200 polyps
Risk of colorectal cancer
Mean age for colon cancer in juvenile polyposis patients is 35 years
Risk is approximately 68% by 60 years of age


Size is variable, but most measure around 1.0 cm in greatest dimension
Majority of polyps (> 2/3) are pedunculated


- Marked expansion of lamina propria by loose, edematous, and inflamed stroma
- Epithelial component is cystically dilated and shows variable degree of inflammation
- Surface ulceration may be present
- Gastric polyps resemble hyperplastic polyps or those seen in Cronkhite-Canada syndrome
- Dysplastic change or carcinoma may be present in syndromic patients (JPS).


- juvenile polyposis (JP) (MIM.174900) (MADH4 and BMPR1A mutations)
- Cowden syndrome (CS) (MIM.158350) (PTEN mutations)
- Bannayan-Riley-Ruvalcaba syndrome (BRRS) (MIM.153480) (PTEN mutations)
- neurofibromatosis type 1 (NF1) (15150783)

NB: Although solitary juvenile polyps are benign lesions, but when present in juvenile polyposis (JP), they may lead to gastrointestinal cancers.


- Merg A, Howe JR. Genetic conditions associated with intestinal juvenile polyps. Am J Med Genet C Semin Med Genet. 2004 Aug 15;129(1):44-55. PMID: 15264272