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adenoviral hepatitis

Tuesday 13 April 2004

Synopsis

- necrotizing hepatitis (#15257556#)
- massive hepatic necrosis
- acute liver failure (#15257556#)
- intranuclear inclusions confined to the liver
- degenerating hepatocytes around focal necrosis
- hepatocytic nuclear inclusion bodies

Electron microscopy

- crystalline arrays of virions within hepatocytes

Associations

- immunosuppression

  • chemotherapy (#17278117#)
  • rituximab therapy (#17090202#)
  • small bowel allograft (#12865807#)
  • liver allograft (#2153017#)
  • bone marrow allograft (#12708923#)
  • severe combined immunodeficiency (SCID) (#6093498#, #3039794#)

References

- Steiner I, Aebi C, Ridolfi Luthy A, Wagner B, Leibundgut K. Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007 Feb 2; PMID: #17278117#

- Longerich T, Haferkamp K, Tox U, Schirmacher P. Acute liver failure in a renal transplant patient caused by adenoviral hepatitis superimposed on a fibrosing cholestatic hepatitis B. Hum Pathol. 2004 Jul;35(7):894-7. PMID: #15257556#

- Wang WH, Wang HL. Fulminant adenovirus hepatitis following bone marrow transplantation. A case report and brief review of the literature.
Arch Pathol Lab Med. 2003 May;127(5):e246-8. PMID: #12708923#

- Kaur B, Gottardo NG, Keil AD, Hallam LA, Baker DL. A rare case of adenoviral fulminant hepatic necrosis after chemotherapy. Pediatr Hematol Oncol. 2002 Jul-Aug;19(5):361-71. PMID: #12078868#

- Bertheau P, Parquet N, Ferchal F, Gluckman E, Brocheriou C. Fulminant adenovirus hepatitis after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1996 Feb;17(2):295-8. PMID: #8640184#

- Charles AK, Caul EO, Porter HJ, Oakhill A. Fatal adenovirus 32 infection in a bone marrow transplant recipient. J Clin Pathol. 1995 Aug;48(8):779-81. PMID: #7560211#

- Salt A, Sutehall G, Sargaison M, Woodward C, Barnes ND, Calne RY, Wreghitt TG. Viral and toxoplasma gondii infections in children after liver transplantation. J Clin Pathol. 1990 Jan;43(1):63-7. PMID: #2155947#

- Cames B, Rahier J, Burtomboy G, de Ville de Goyet J, Reding R, Lamy M, Otte JB, Sokal EM. Acute adenovirus hepatitis in liver transplant recipients. J Pediatr. 1992 Jan;120(1):33-7. PMID: #1731021#

- Johnson PR, Yin JA, Morris DJ, Desai M, Cinkotai KI, McKeogh MM. Fulminant hepatic necrosis caused by adenovirus type 5 following bone marrow transplantation. Bone Marrow Transplant. 1990 May;5(5):345-7. PMID: #2161693#

- Krilov LR, Rubin LG, Frogel M, Gloster E, Ni K, Kaplan M, Lipson SM. Disseminated adenovirus infection with hepatic necrosis in patients with human immunodeficiency virus infection and other immunodeficiency states. Rev Infect Dis. 1990 Mar-Apr;12(2):303-7. PMID: #2158668#

- Varki NM, Bhuta S, Drake T, Porter DD. Adenovirus hepatitis in two successive liver transplants in a child. Arch Pathol Lab Med. 1990 Jan;114(1):106-9. PMID: #2153017#

- Koneru B, Jaffe R, Esquivel CO, Kunz R, Todo S, Iwatsuki S, Starzl TE. Adenoviral infections in pediatric liver transplant recipients. JAMA. 1987 Jul 24-31;258(4):489-92. PMID: #3037128#

- Ohbu M, Sasaki K, Okudaira M, Iidaka K, Aoyama Y. Adenovirus hepatitis in a patient with severe combined immunodeficiency. Acta Pathol Jpn. 1987 Apr;37(4):655-64. PMID: #3039794#

- Rodriguez FH Jr, Liuzza GE, Gohd RH. Disseminated adenovirus serotype 31 infection in an immunocompromised host. Am J Clin Pathol. 1984 Nov;82(5):615-8. PMID: #6093498#

- Carmichael GP Jr, Zahradnik JM, Moyer GH, Porter DD. Adenovirus hepatitis in an immunosuppressed adult patient. Am J Clin Pathol. 1979 Mar;71(3):352-5. PMID: #219683#

Portfolio

  • Hepatic necrosis in adenoviral hepatitis
  • Hepatic necrosis in adenoviral hepatitis
  • Hepatic necrosis in adenoviral hepatitis