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parathyroid tumors

Tuesday 27 April 2004

Images

- parathyroid carcinoma

Digital cases

- JRC:15047 : Parathyroid adenoma, with bizarre cells
- JRC:18765 : Parathyroid carcinoma
- JRC:9410 : Parathyroid carcinoma

Types

- parathyroid hyperplasia
- parathyroid adenoma
- parathyroid carcinoma

Synopsis

- parathyroid carcinoma

  • increased mitoses
  • vascular invasion
  • broad bands of fibrosis

Molecular biology

- allelic loss regions

  • 1p LOH
  • 1q25 LOH
  • 7q13.3 LOH
  • 10q23 LOH
  • 11p15.5 LOH
  • 13q14.3 LOH

- benign parathyroid diseases (adenomas and hyperplasia) had low mean fractional allelic loss (11% and 15%) (16006799)
- parathyroid carcinomas (63%) (16006799)

References

- Parathyroid tumors and related disorders. DeLellis RA. Mod Pathol. 2011 Apr;24 Suppl 2:S78-93. doi : 10.1038/modpathol.2010.132 PMID: 21455204 [Free]

- Haven CJ, Howell VM, Eilers PH, Dunne R, Takahashi M, van Puijenbroek M, Furge K, Kievit J, Tan MH, Fleuren GJ, Robinson BG, Delbridge LW, Philips J, Nelson AE, Krause U, Dralle H, Hoang-Vu C, Gimm O, Morreau H, Marsh DJ, Teh BT. Gene expression of parathyroid tumors: molecular subclassification and identification of the potential malignant phenotype. Cancer Res. 2004 Oct 15;64(20):7405-11. PMID: 15492263

- Hunt JL, Carty SE, Yim JH, Murphy J, Barnes L. Allelic loss in parathyroid neoplasia can help characterize malignancy. Am J Surg Pathol. 2005 Aug;29(8):1049-55. PMID: 16006799

- Erickson LA, Jalal SM, Harwood A, Shearer B, Jin L, Lloyd RV. Analysis of Parathyroid Neoplasms by Interphase Fluorescence In Situ Hybridization. Am J Surg Pathol. 2004 May;28(5):578-584. PMID: 15105644