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FOXA2

MIM.600288 20p11

Monday 3 May 2004

HNF3B

Definition : Foxa2 (Hnf3beta) is a winged-helix/forkhead transcription factor that regulates gene expression in the liver, pancreatic islets and adipocytes. It is required for the maintenance of glucose and lipid homeostasis.

Function

- FOXA2 controls PDX1 gene expression in pancreatic beta-cells in vivo (12145169)

Pathology

- FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate. (28621319)

Animal models

- Hyperinsulinemia-mediated inactivation of Foxa2 by nuclear exclusion has recently been implicated in the development of liver steatosis and insulin resistance in three animal models of diabetes.

Open references

- FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.
Park JW, Lee JK, Witte ON, Huang J.
Mod Pathol. 2017 Sep;30(9):1262-1272. doi : 10.1038/modpathol.2017.44
PMID: 28621319 Free

References

- Wang H, Wollheim CB. Does chasing selected ’Fox’ to the nucleus prevent diabetes? Trends Mol Med. 2005 Jun;11(6):262-5. PMID: 15949766