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giant cell transformation

Thursday 19 June 2003

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- Case 108 (HPC:108) : Giant cell transformation of hepatocytes
- Case 55 (HPC:55) : Giant cell transformation of hepatocytes in cholestatic cirrhosis

Etiology

- viral hepatitis

  • cytomegalovirus hepatitis (CMV hepatitis)
  • rubella virus hepatitis
  • herpes simplex virus hepatitis (HSV hepatitis)
  • HPV
  • HHV-6 hepatitis
  • varicella hepatitis
  • coxsackievirus hepatitis
  • echovirus hepatitis
  • reovirus 3 hepatitis
  • parvovirus B19 hepatitis
  • HIV hepatitis
  • enterovirus hepatitis
  • paramyxovirus hepatitis
  • hepatitis A
  • hepatitis B
  • hepatitis C (rare)

- bacterial hepatitis

- parasitic hepatitis (protozoan hepatitis)

- Cholestasis

  • extra-hepatic biliary atresia
  • choledochal cyst
  • intrahepatic bile duct paucity (biliary ductopenia) and Alagille disease
  • hepatic cystic fibrosis
  • familial intrahepatic cholestatic syndromes (FIHC)
  • bile acid synthetic diseases (inborn errors of bile acid synthesis)

- chromosomal anomalies

  • trisomy 21
  • trisomy 18
  • monosomy X

- metabolic diseases

  • alpha-1-antitrypsin deficiency
  • galactosemia
  • Niemann-Pick diseases
  • Gaucher diseases
  • mucolipidoses
  • cerebrohepatorenal syndrome (Zellweger syndrome)
  • acute tyrosinemia
  • some mitochondriopathies
  • some peroxysomopathies

- autoimmune diseases (immunohemolytic diseases)
- autoimmune hemolytic anemia (GCHAIHA)

- cardiovascuar diseases

  • endocardial cushion defect
  • anomalous pulmonary venous return

- neonatal hemochromatosis (fetal massive hepatic necrosis)

Associations

- neonatal hemochromatosis (idiopathic iron storage syndrome)
- Arnold-Chiari malformation

See also

- neonatal hepatitis
- syncitial cells

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