Humpath.com - Human pathology

Home > C. Tissular pathology > acantholysis

acantholysis

Tuesday 1 June 2004

Definition: disruption of the squamous epithelium. The desmosomal connections between the epithelial cells are destroyed. As a result the cells separate and become round.

ACANTHOLYSIS (or lack of cell adhesion) is a finding sometimes observed in squamous cell carcinoma.

Images : acantholytic anomalies

- In grover disease

- acanthotic squamous cell carcinoma

References

- Dhitavat J, Fairclough RJ, Hovnanian A, Burge SM. Calcium pumps and keratinocytes: lessons from Darier’s disease and Hailey-Hailey disease. Br J Dermatol. 2004 May;150(5):821-8. PMID: 15149492