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NTRK3

Thursday 3 June 2004

TrkC; TRKC

Definition: TrkC is a member of the Trk family of tyrosine kinase receptors and plays an important role in the development and maintenance of neural tissues.

Pathology

- ETV6-NTRK3 fusion gene by translocation t(12;15)(p13;q25)

- NTRK3 signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. (23027130)

- NTRK3 fusion genes in fibrosarcomas (30520818)

  • NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors.
  • CD34-positive fibrosarcoma of bone and soft tissue could be a good candidate for NTRK testing.
  • STRN-NTRK3 and STRN3-NTRK fusion genes

See also

- NTRKs

References

- Hisaoka M, Sheng WQ, Tanaka A, Hashimoto H. Gene expression of TrkC (NTRK3) in human soft tissue tumours. J Pathol. 2002 Aug;197(5):661-7. PMID: 12210087