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ductular reaction

Wednesday 25 June 2003

Definition: Increase in the number and prominence of small biliary channels in and around the portal tracts.

Synopsis:

- tubular to elongated profiles
- lined by cuboidal or columnar epithelium
- well-defined lumen or not

Etiology:

- acute or chronic cholestasis
- sepsis
- massive hepatic necrosis
- hepatic fibrosis
- hepatic cirrhosis
- miscellaneous

  • nephronophthisis-associated hepatic disease
  • hepatic Ellis-van Creveld disease

Elementary lesions associated:

- bile plugs
- ductular dilatation
- neutrophilic infiltration

Differential diagnosis:

- must be distinguished from interlobular bile ducts

Portfolio

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  • Ductular reaction or ductular proliferation (cytokeratin-7)
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  • Ductular proliferation in North American Indian cirrhosis (CK19)
  • Ductular proliferation in North American Indian cirrhosis (CK19)
  • Ductular proliferation in North American Indian cirrhosis (CK19)