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EBV-associated lymphoproliferative diseases

Sunday 22 August 2004

Digital case

- HPC:333 : EBV-associated infectious mononucleosis (Lymph node)

Types

- EBV-associated infectious mononucleosis
- systemic EBV-positive T-cell lymphoproliferative disease of childhood (ICD-0 9724/3)

Predisposition

- immunodeficiency

  • allograft (post-transplant lymphoproliferative disorder - PTLD)
  • constitutional immunodeficiency (primary immunodeficiencies)
    • Wiskott-Aldrich disease

References

- Thorley-Lawson DA, Gross A. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N Engl J Med. 2004 Mar 25;350(13):1328-37. PMID: 15044644