BIRC4

It’s well recognized that X-linked inhibitor of apoptosis (XIAP) was the most potent caspase inhibitor (CASPs inhibitor) and second mitochondria-derived activator of caspase (DIABLO or Smac; HGNC21528) was the antagonist of XIAP.

Pathology

 X-linked inhibitor of apoptosis positive nuclear labeling is an independent prognostic biomarker of breast invasive ductal carcinoma.

• Experiments in vitro identified that down regulation of XIAP expression or applying DIABLO mimics could sensitize breast cancer cells to chemotherapeutics and promote apoptosis.
• However, expression status and biologic or prognostic significance of XIAP/Smac in breast invasive ductal carcinoma (IDC) were not clear.
• Disturbed balance of expression between XIAP and Smac probably contributed to carcinogenesis and XIAP positive nuclear labeling was a new independent prognostic biomarker of breast IDC.

 XIAP expression is an independent prognostic marker in clear-cell renal carcinomas (15297970)

References

 X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma. Zhang Y, Zhu J, Tang Y, Li F, Zhou H, Peng B, Zhou C, Fu R. Diagn Pathol. 2011 Jun 7;6:49. PMID: 21645409 [Free]