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IDs

Thursday 26 August 2004

Id proteins

ID proteins contain a helix-loop-helix (HLH) motif and regulate tissue-specific transcription within several cell lineages. They do not bind DNA directly, but inhibit lineage commitment by binding basic helix-loop-helix (bHLH) transcription factors through their HLH motif. ID proteins contribute to cell growth, senescence, differentiation, angiogenesis, invasion and migration.

Members

ID1 ID2 ID3 ID4

See also

- HLH proteins : HLHs

References

- Perk J, Iavarone A, Benezra R. Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer. 2005 Aug;5(8):603-14. PMID: 16034366

- Fong S, Debs RJ, Desprez PY. Id genes and proteins as promising targets in cancer therapy. Trends Mol Med. 2004 Aug;10(8):387-92. PMID: 15310459