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Tourette syndrome

Friday 3 September 2004

Gilles de la Tourette syndrome (GTS) is characterized by multiple motor and phonic tics and high comorbidity rates with other neurobehavioral disorders. It is hypothesized that frontal-subcortical pathways and a complex genetic background are involved in the etiopathogenesis of the disorder.

Susceptibility

- germline mutations of SLITRK1 at 17q25

References

- Grados MA, Walkup JT. A new gene for Tourette’s syndrome: a window into causal mechanisms? Trends Genet. 2006 Jun;22(6):291-3. PMID: 16678301