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melanoma

Monday 13 June 2011

melanomas ; malignant melanoma

Images

- Melanoma FNA

Digital cases

- UI:1827 - Cutaneous malignant melanoma, solar damage
- UI:347 - Cutaneous malignant melanoma.
- JRC:111 : Metastatic malignant melanoma in a lymph node.
- JRC:3168 : Metastatic malignant melanoma in the ovary.
- JRC:10632 : Cutaneous spindle cell melanoma.
- JRC:10642 : Cutaneous melanoma (In Situ Hutchinson).
- JRC:10647 : Cutaneous melanoma.
- JRC:10650 : Cutaneous melanoma in a child.
- JRC:14087 : Pulmonary metastasis of a melanoma.
- JRC:14614 : Metastatic malignant melanoma (vs primary CNS-type melanoma vs malignant epithelioid schwannoma).
- Malignant Melanoma, Liver FNA by Ed Euthman

Melanoma incidence has been rising steadily for decades, whereas mortality rates have remained flat.

Differential diagnosis

- Ancillary tests, such as fluorescent in situ hybridization (FISH), are now being used to help differentiate melanomas from melanocytic nevi. Multicolor FISH has been shown to distinguish between these 2 with 86.7% sensitivity and 95.4% specificity. (21716079)

Localization

- cutaneous melanoma
- meningeal melanoma
- uveal melanoma

Cytology of melanoma by FNA

- Malignant Melanoma, Liver FNA by Ed Euthman

Reporting

- https://www.melanoma.org/understand-melanoma/diagnosing-melanoma/melanoma-pathology

Sequencing

Video : Comparison of primary and metastatic acral melanoma by whole genome sequencing.

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References

- Assessment of copy number status of chromosomes 6 and 11 by FISH provides independent prognostic information in primary melanoma. North JP, Vetto JT, Murali R, White KP, White CR Jr, Bastian BC. Am J Surg Pathol. 2011 Aug;35(8):1146-50. PMID: 21716079

- Clinical Relevance of Detection of Lymphovascular Invasion in Primary Melanoma Using Endothelial Markers D2-40 and CD34. Rose AE, Christos PJ, Lackaye D, Shapiro RL, Berman R, Mazumdar M, Kamino H, Osman I, Darvishian F. Am J Surg Pathol. 2011 Aug 29. PMID: 21881483

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